QUANTITATIVE ORGANIC ACID PROFILE

The key to managing chronic Eating Disorders
Organic acids are formed in various tissues or by intestinal microbes as metabolic intermediates or end products. Accumulations of organic acids in urine can indicate metabolic dysfunction, nutrient insufficiencies, or even microbial overgrowth. Abnormal levels of organic acids can be traced to inherited or acquired enzyme deficiencies, build-up of toxicants, specific nutrient deficiencies, or drug effects.

Improvement of health by identifying metabolic factors
The origin of chronic illness is a combination of genetic tendencies, nutrient insufficiencies, and other environmental influences negatively impacting overall metabolic function. Effective primary intervention focuses on correcting problems at this metabolic level. Quantitative analysis of organic acids in urine reveals much about a patient's metabolic status. The New Organix Profile provides a toll to focus intervention at this functional level to restore health, For example, the New Organix Profile can help identify metabolic factors relating to...

Obesity
Obesity is epidemic and contributes directly to the development of many chronic, degenerative diseases. Patients seek your help after becoming frustrated with their efforts to lose weight. Your ability to pinpoint key cellular energetics issues that respond to targeted nutrient interventions can resolve years of misdirected dietary restrictions. The Organix Profile reveals numerous metabolic factors other than caloric or fat intakes that have effects on body weight. The most common interventions involve optimal doses of essential amino acids, carnitine, and vitamin-derived cofactors for energy pathways. Such predictive metabolomics allow you to assess metabolic efficiency. Addressing these issues at the functional level is far more efficient than searching for potential influences with predictive genomics testing. Metabolic profiling with the Organix Profile gives you direct insight into fatty acid, amino acid, and carbohydrate metabolism as well as nutrient deficiencies related to carnitine, chromium, vanadium, B vitamins, and lipoic acid. All have been implicated in obesity.

Adipate, Suberate, Ethylmalonate, Pyruvate, Lactate, beta-Hydroxybutyrate

Intestinal Disorders
The successful management of intestinal disorders requires a comprehensive viewpoint. The New Organix Profile includes unique, non-human metabolic compounds produced by potential pathogens within the gut. Elevations of these compounds let you evaluate microbial origins gastro intestinal symptoms. When offending organisms grow predominantly in the small intestine, stool tests can be negative, yet high levels of their by-products appear in urine. The patterns of compounds allow discrimination of bacterial or fungal organisms and their relative amounts of overgrowth. In addition, the protozoan, Giardia, produces a unique compound that is reported.

Evaluation of patients with chronic gastrointestinal complaints is improved with Organix profiling by allowing a more expanded view of potential causes. The simultaneous measurement of detoxification markers adds another dimension of effectiveness to your treatment plan.

Analytes: 12 (twelve) Dysbiosis markers and 5 (five) Detoxification indicators

"Among the 10 patients whose urinary excretion of the urinate (p-hydroxyhenylacetate) was considered to be abnormal were patients with Giardia lamblia infestation, ileal resection with blind loop, and other diseases of the small intestine associated with bacterial overgrowth. We conclude that measurement of p-hydroxypheny-lacetate excretions useful for such diseases."

Depression
The recent surge in popularity of natural or alternative treatments for depression has demonstrated the usefulness of vitamins, amino acids, fatty acids, and minerals for neurotransmitter control. However, every patient is biochemically unique and requires a targeted approach. Nutritional needs vary based on genetics, risk factors, and lifestyle. The New Organix Profile helps to identify depressed patients who may benefit from specific nutritional approaches. No other single assessment tool provides simultaneous markers of B-vitamin status, methlyation cofactors, neurotransmitter metabolism, and amino acids. Since unmet needs for vitamins B6 or BIZ, folic acid, and serotonin or catecholamine precursor amino acids can exacerbate depressive tendencies, identifying any one of these factors may help in the management of your clinically depressed patients.

Analytes: Xanthurenate, Methylmalonate, formiminoglutamate, Kynurenate, Pyroglutamate, Sulfate, Vanilmandelate, Homo-vanillate,  5-Hydroxyindoleacetate, Orotate, and Fumarate

“The levels of the urinary main metabolites of.. .dopamine homovanillic acid (HVA)] and of serotonin [ 5 -hydroxy-indoleacetic acid (5-HIAA)] were measured in 84 patients with major depressive disorder. Female patients with delusional major depression had significantly higher HVA excretion than female patients with non-delusional major deression (p = 0.036). 5-HIAA excretion was similar in the two patient subgroups [delusional and non delusional].”

Chronic Fatigue
Most patients experiencing chronic fatigue have multiple factors impacting energy production. Low thyroid and adrenal function, psychological stress, toxic overload poor dietary habits, lack of exercise, sleep cycle disruptions, chronic pain, and inadequate nutrition status can all play a role. Assessing mitochondrial dysfunction may be the key to breaking the energy blockade. If the basic energy-generating system is blocked or sluggish, cells cannot meet their metabolic needs. Over time, this diminished capacity creates organ weakness and a profound fatigue, which is evidenced by accumulated citric acid cycle intermediates in the urine. These accumulations serve as functional markers for coenzyme deficiencies, indicating need for aggressive B-complex vitamin supplementation to alleviate fatigue.

Analytes: alpha-Ketoglutarate, Succinate, Fumarate, Malate, Cis-Aconitate, Citrate, and Isocitrate

"Vitamin-dependent activities.. .provide preliminary evidence of reduced functional B vitamin status, particularly of pyridoxine, in CFS patients.”

Cardiovascular Disease
Nutritional assessments may have a more profound impact on heart disease risk than better-known risk assessments such as lipid profiling. Identifying individuals who are deficient in coenzyme Q10 and other cardio-protective nutrients should routinely be part of any comprehensive risk reduction plan. Metabolic testing with the New Organix Profile provides evidence for the use of nutrient therapies to reduce vascular events in your patients. Cholesterol lowering drugs can inhibit the production of CoQ10. Vitamin B12, folic acid, and vitamin B6 can reduce the powerful endothelial risk factor, homocysteine. While serum assays for these nutrients may not reflect their cardiovascular system functional status, the New Organix Profile includes specific biomarkers that reveal your patient's need for pyridoxine, folate, vitamin Biz, and CoQIO.
Analytes: Succinate, Xanthurenate, Kynurenate, Formiminoglutamate, and Methylmalonate

"Metagenics has documented a highly significant reduction in the occurrence of vascular events during 539 patient years of treatment in 32 patients with cystathionine beta synthase deficiency (mean age 30 years, range 9-66 years) by aggressive homocyst(e)ine lowering with pyridoxine, folic acid, and B12p = 0.0001).”